Research

Advances in Stepped Wedge Design: A Comprehensive Review Published

Soumadeb Pain and Satya Prakash Singh · SSCA Special Conference Proceedings, 2025

A review of stepped wedge cluster randomized trials, covering design variants, statistical models, sample-size methods, correlation structures, unequal cluster sizes, Bayesian optimal design, non-normal outcomes, and staircase designs.

Optimal Cohort Stepped Wedge Designs with Unequal Cluster Sizes Under review

Soumadeb Pain and Satya Prakash Singh · under review at Computational Statistics and Data Analysis

Optimal Cohort Staircase Designs Preprint

Soumadeb Pain and Satya Prakash Singh · arXiv preprint, 2026

Develops an optimal design framework for closed-cohort staircase trials with continuous outcomes and unequal cluster sizes, including theoretical characterization of optimal allocations, joint optimization of sequence allocation and cluster sizes, and efficiency and cost comparisons with stepped-wedge designs.

Other academic projects
  • Non-linear regression using numerical methods
  • Jackknife estimation in non-linear regression
  • ESM-IF-driven protein engineering for subunit-based vaccine candidate design against West Nile Virus